Bimodal modulation of the botulinum neurotoxin protein-conducting channel

Clostridium botulinum neurotoxin (BoNT) is the causative agent of botulism, a neuroparalytic disease. We describe here a semisynthetic strategy to identify inhibitors based on toosendanin, a traditional Chinese medicine reported to protect from BoNT intoxication. Using a single molecule assay of BoN...

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Autors principals: Fischer, Audrey, Nakai, Yuya, Eubanks, Lisa M., Clancy, Colin M., Tepp, William H., Pellett, Sabine, Dickerson, Tobin J., Johnson, Eric A., Janda, Kim D., Montal, Mauricio
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2009
Matèries:
Physical Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2635780/
https://ncbi.nlm.nih.gov/pubmed/19164566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0812839106
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