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Bimodal modulation of the botulinum neurotoxin protein-conducting channel
Clostridium botulinum neurotoxin (BoNT) is the causative agent of botulism, a neuroparalytic disease. We describe here a semisynthetic strategy to identify inhibitors based on toosendanin, a traditional Chinese medicine reported to protect from BoNT intoxication. Using a single molecule assay of BoN...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2635780/ https://ncbi.nlm.nih.gov/pubmed/19164566 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0812839106 |
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