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Translocation of Botulinum neurotoxin light chain protease by the heavy chain protein-conducting channel
Clostridial botulinum neurotoxins (BoNTs) inhibit synaptic exocytosis; intoxication requires the di-chain protein to undergo conformational changes in response to pH and redox gradients across the endosomal membrane with consequent formation of a protein-conducting channel by the heavy chain (HC) th...
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| Hlavní autor: | |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2008
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2782371/ https://ncbi.nlm.nih.gov/pubmed/19111565 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.toxicon.2008.11.018 |
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