Llwytho...

Evaluation of adamantane hydroxamates as botulinum neurotoxin inhibitors: synthesis, crystallography, modeling, kinetic and cellular based studies

Botulinum neurotoxins (BoNTs) are the most lethal biotoxins known to mankind and are responsible for the neuroparalytic disease botulism. Current treatments for botulinum poisoning are all protein based and thus have a limited window of treatment opportunity. Inhibition of the BoNT light chain prote...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Šilhár, Peter, Silvaggi, Nicholas R., Pellett, Sabine, Čapková, Kateřina, Johnson, Eric A., Allen, Karen N., Janda, Kim D.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2012
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3574188/
https://ncbi.nlm.nih.gov/pubmed/23340139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2012.12.001
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