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Botulinum Neurotoxin A Protease: Discovery of Natural Product Exosite Inhibitors
[Image: see text] A new mechanistic class of BoNT/A zinc metalloprotease inhibitors, from Echinacea, exemplified by the natural product Dchicoric acid (I1) is disclosed. A detailed evaluation of chicoric acid's mechanism of inhibition reveals that the inhibitor binds to an exosite, displays non...
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| Главные авторы: | , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2010
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2832098/ https://ncbi.nlm.nih.gov/pubmed/20158239 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja910761y |
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