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Botulinum Neurotoxin A Protease: Discovery of Natural Product Exosite Inhibitors

[Image: see text] A new mechanistic class of BoNT/A zinc metalloprotease inhibitors, from Echinacea, exemplified by the natural product Dchicoric acid (I1) is disclosed. A detailed evaluation of chicoric acid's mechanism of inhibition reveals that the inhibitor binds to an exosite, displays non...

詳細記述

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書誌詳細
主要な著者: Šilhár, Peter, Čapková, Kateřina, Salzameda, Nicholas T., Barbieri, Joseph T., Hixon, Mark S., Janda, Kim D.
フォーマット: Artigo
言語:Inglês
出版事項: 2010
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2832098/
https://ncbi.nlm.nih.gov/pubmed/20158239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja910761y
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