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Evaluation of adamantane hydroxamates as botulinum neurotoxin inhibitors: synthesis, crystallography, modeling, kinetic and cellular based studies

Botulinum neurotoxins (BoNTs) are the most lethal biotoxins known to mankind and are responsible for the neuroparalytic disease botulism. Current treatments for botulinum poisoning are all protein based and thus have a limited window of treatment opportunity. Inhibition of the BoNT light chain prote...

תיאור מלא

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מידע ביבליוגרפי
Main Authors: Šilhár, Peter, Silvaggi, Nicholas R., Pellett, Sabine, Čapková, Kateřina, Johnson, Eric A., Allen, Karen N., Janda, Kim D.
פורמט: Artigo
שפה:Inglês
יצא לאור: 2012
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3574188/
https://ncbi.nlm.nih.gov/pubmed/23340139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2012.12.001
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