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Synthesis/biological evaluation of hydroxamic acids and their prodrugs as inhibitors for Botulinum neurotoxin A light chain

Botulinum neurotoxin A (BoNT/A) is the most potent toxin known. Unfortunately, it is also a potential bioweapon in terrorism, which is without an approved therapeutic treatment once cellular intoxication takes place. Previously, we reported how hydroxamic acid prodrug carbamates increased cellular u...

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Autores principales: Seki, Hajime, Pellett, Sabine, Šilhár, Peter, Stowe, G. Neil, Blanco, Beatriz, Lardy, Matthew, Johnson, Eric A., Janda, Kim D.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2013
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3919520/
https://ncbi.nlm.nih.gov/pubmed/24360826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2013.11.053
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