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Targeting Botulinum A Cellular Toxicity: A Prodrug Approach

The botulinum neurotoxin light chain (LC) protease has become an important therapeutic target for post-exposure treatment of botulism. Hydroxamic acid based small molecules have proven to be potent inhibitors of LC/A with nanomolar K(i) values, yet, they lack cellular activity conceivably due to low...

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Bibliografski detalji
Glavni autori: Šilhár, Peter, Eubanks, Lisa M., Seki, Hajime, Pellett, Sabine, Javor, Sacha, Tepp, William H., Johnson, Eric A., Janda, Kim D.
Format: Artigo
Jezik:Inglês
Izdano: 2013
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3880648/
https://ncbi.nlm.nih.gov/pubmed/24127873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm400873n
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