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Targeting Botulinum A Cellular Toxicity: A Prodrug Approach
The botulinum neurotoxin light chain (LC) protease has become an important therapeutic target for post-exposure treatment of botulism. Hydroxamic acid based small molecules have proven to be potent inhibitors of LC/A with nanomolar K(i) values, yet, they lack cellular activity conceivably due to low...
Wedi'i Gadw mewn:
| Prif Awduron: | , , , , , , , |
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| Fformat: | Artigo |
| Iaith: | Inglês |
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2013
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| Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3880648/ https://ncbi.nlm.nih.gov/pubmed/24127873 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm400873n |
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