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Synthesis and Structure-Activity Relationships of Second-Generation Hydroxamate Botulinum Neurotoxin A Protease Inhibitors
Botulinum neurotoxins are the most toxic proteins currently known. Based on a recently identified potent lead structure, 2,4-dichlorocinnamic acid hydroxamate, herein we report on the structure-activity relationship of a series of hydroxamate BoNT/A inhibitors. Among them, 2-bromo-4-chlorocinnamic a...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2170532/ https://ncbi.nlm.nih.gov/pubmed/17951059 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2007.09.103 |
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