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Synthesis and evaluation of library of betulin derivatives against the botulinum neurotoxin A protease
Botulinum neurotoxins (BoNTs) are the most toxic proteins currently known. Current treatments for botulinum poisoning are all protein based with a limited window of opportunity. Inhibition of the BoNT light chain protease (LC) has emerged as a new therapeutic strategy for the treatment of botulism a...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2011
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3070790/ https://ncbi.nlm.nih.gov/pubmed/21421315 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2011.02.115 |
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