Chirality Holds the Key for Potent Inhibition of the Botulinum Neurotoxin Serotype A Protease

[Image: see text] Botulinum neurotoxin serotype A (BoNT/A) is the most toxic protein known to man, and also a bioterrorism agent. As defined by our previous research targeting the etiological agent responsible for BoNT/A intoxication, a protease, we now report on the asymmetric synthesis of four new...

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Библиографические подробности
Главные авторы: Stowe, G. Neil, Šilhár, Peter, Hixon, Mark S., Silvaggi, Nicholas R., Allen, Karen N., Moe, Scott T., Jacobson, Alan R., Barbieri, Joseph T., Janda, Kim D.
Формат: Artigo
Язык:Inglês
Опубликовано: 2010
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2821465/
https://ncbi.nlm.nih.gov/pubmed/20092262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol902820z
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