Regulation of Iron Metabolism by Hepcidin under Conditions of Inflammation

Por Schmidt, Paul J.
Publicado no J Biol Chem (2015)

Transgenic HFE-dependent induction of hepcidin in mice does not require transferrin receptor-2

Por Schmidt, Paul J., Fleming, Mark D.
Publicado em 2012

Modulation of hepcidin as therapy for primary and secondary iron overload disorders: pre-clinical models and approaches

Por Schmidt, Paul J., Fleming, Mark D.
Publicado em 2014

Hepcidin induction by transgenic overexpression of Hfe does not require the Hfe cytoplasmic tail, but does require hemojuvelin

Por Schmidt, Paul J., Andrews, Nancy C., Fleming, Mark D.
Publicado em 2010

Murine mutants in the study of systemic iron metabolism and its disorders: an update on recent advances

Por Bartnikas, Thomas B., Fleming, Mark D., Schmidt, Paul J.
Publicado em 2012

Effects of Testosterone on Erythropoiesis in a Female Mouse Model of Anemia of Inflammation

Por Guo, Wen, Schmidt, Paul J., Fleming, Mark D., Bhasin, Shalender
Publicado no Endocrinology (2016)

Transferrin receptor modulates Hfe-dependent regulation of hepcidin expression

Por Schmidt, Paul J., Toran, Paul T., Giannetti, Anthony M., Bjorkman, Pamela J., Andrews, Nancy C.
Publicado em 2008

Combination therapy with a Tmprss6 RNAi-therapeutic and the oral iron chelator deferiprone additively diminishes secondary iron overload in a mouse model of β-thalassemia intermedi...

Por Schmidt, Paul J, Racie, Tim, Westerman, Mark, Fitzgerald, Kevin, Butler, James S, Fleming, Mark D
Publicado no Am J Hematol (2015)

SIRT3 regulates cellular iron metabolism and cancer growth by repressing iron regulatory protein 1

Por Jeong, Seung Min, Lee, Jaewon, Schmidt, Paul J., Fleming, Mark D., Haigis, Marcia C.
Publicado no Oncogene (2014)

An RNAi therapeutic targeting Tmprss6 decreases iron overload in Hfe(−/−) mice and ameliorates anemia and iron overload in murine β-thalassemia intermedia

Por Schmidt, Paul J., Toudjarska, Iva, Sendamarai, Anoop K., Racie, Tim, Milstein, Stuart, Bettencourt, Brian R., Hettinger, Julia, Bumcrot, David, Fleming, Mark D.
Publicado em 2013

BMP6 treatment compensates for the molecular defect and ameliorates hemochromatosis in Hfe knockout mice

Por Corradini, Elena, Schmidt, Paul J., Meynard, Delphine, Garuti, Cinzia, Montosi, Giuliana, Chen, Shanzhuo, Vukicevic, Slobodan, Pietrangelo, Antonello, Lin, Herbert Y., Babitt, Jodie L.
Publicado em 2010

HFE interacts with the BMP type I receptor ALK3 to regulate hepcidin expression

Por Wu, Xing-gang, Wang, Yang, Wu, Qian, Cheng, Wai-Hang, Liu, Wenjing, Zhao, Yueshui, Mayeur, Claire, Schmidt, Paul J., Yu, Paul B., Wang, Fudi, Xia, Yin
Publicado no Blood (2014)

A competitive enzyme-linked immunosorbent assay specific for murine hepcidin-1: correlation with hepatic mRNA expression in established and novel models of dysregulated iron homeos...

Por Gutschow, Patrick, Schmidt, Paul J., Han, Huiling, Ostland, Vaughn, Bartnikas, Thomas B., Pettiglio, Michael A., Herrera, Carolina, Butler, James S., Nemeth, Elizabeta, Ganz, Tomas, Fleming, Mark D., Westerman, Mark
Publicado no Haematologica (2015)

Transferrin receptor 1 is a cellular receptor for New World haemorrhagic fever arenaviruses

Por Radoshitzky, Sheli R., Abraham, Jonathan, Spiropoulou, Christina F., Kuhn, Jens H., Nguyen, Dan, Li, Wenhui, Nagel, Jane, Schmidt, Paul J., Nunberg, Jack H., Andrews, Nancy C., Farzan, Michael, Choe, Hyeryun
Publicado em 2007

HRG1 is essential for heme transport from the phagolysosome of macrophages during erythrophagocytosis

Por White, Carine, Yuan, Xiaojing, Schmidt, Paul J., Bresciani, Erica, Samuel, Tamika K., Campagna, Dean, Hall, Caitlin, Bishop, Kevin, Calicchio, Monica L., Lapierre, Ariane, Ward, Diane M., Liu, Paul, Fleming, Mark D., Hamza, Iqbal
Publicado em 2013

The IRP1-HIF-2α Axis Coordinates Iron and Oxygen Sensing with Erythropoiesis and Iron Absorption

Por Anderson, Sheila A., Nizzi, Christopher P., Chang, Yuan-I, Deck, Kathryn M., Schmidt, Paul J., Galy, Bruno, Damnernsawad, Alisa, Broman, Aimee T., Kendziorski, Christina, Hentze, Matthias W., Fleming, Mark D., Zhang, Jing, Eisenstein, Richard S.
Publicado em 2013

Pseudouridine synthase 1 deficient mice, a model for Mitochondrial Myopathy with Sideroblastic Anemia, exhibit muscle morphology and physiology alterations

Por Mangum, Joshua E., Hardee, Justin P., Fix, Dennis K., Puppa, Melissa J., Elkes, Johnathon, Altomare, Diego, Bykhovskaya, Yelena, Campagna, Dean R., Schmidt, Paul J., Sendamarai, Anoop K., Lidov, Hart G. W., Barlow, Shayne C., Fischel-Ghodsian, Nathan, Fleming, Mark D., Carson, James A., Patton, Jeffrey R.
Publicado no Sci Rep (2016)

A recurring mutation in the respiratory complex 1 protein NDUFB11 is responsible for a novel form of X-linked sideroblastic anemia

Por Lichtenstein, Daniel A., Crispin, Andrew W., Sendamarai, Anoop K., Campagna, Dean R., Schmitz-Abe, Klaus, Sousa, Cristovao M., Kafina, Martin D., Schmidt, Paul J., Niemeyer, Charlotte M., Porter, John, May, Alison, Patnaik, Mrinal M., Heeney, Matthew M., Kimmelman, Alec, Bottomley, Sylvia S., Paw, Barry H., Markianos, Kyriacos, Fleming, Mark D.
Publicado no Blood (2016)

Physiologic expression of SF3B1(K700E) causes impaired erythropoiesis, aberrant splicing, and sensitivity to pharmacologic spliceosome modulation

Por Obeng, Esther A., Chappell, Ryan J., Seiler, Michael, Chen, Michelle C., Campagna, Dean R., Schmidt, Paul J., Schneider, Rebekka K., Lord, Allegra M., Wang, Lili, Gambe, Rutendo G., McConkey, Marie E., Ali, Abdullah M., Raza, Azra, Yu, Lihua, Buonamici, Silvia, Smith, Peter G., Mullally, Ann, Wu, Catherine J., Fleming, Mark D., Ebert, Benjamin L.
Publicado no Cancer Cell (2016)

X-linked sideroblastic anemia due to ALAS2 intron 1 enhancer element GATA binding site mutations

Por Campagna, Dean R., de Bie, Charlotte I., Schmitz-Abe, Klaus, Sweeney, Marion, Sendamarai, Anoop K., Schmidt, Paul J., Heeney, Matthew M., Yntema, Helger G., Kannengiesser, Caroline, Grandchamp, Bernard, Niemeyer, Charlotte M., Knoers, Nine V.A.M., Swart, Sonia, Marron, Gordon, van Wijk, Richard, Raymakers, Reinier A., May, Alison, Markianos, Kyriacos, Bottomley, Sylvia S., Swinkels, Dorine W., Fleming, Mark D.
Publicado em 2013