Combination therapy with a Tmprss6 RNAi-therapeutic and the oral iron chelator deferiprone additively diminishes secondary iron overload in a mouse model of β-thalassemia intermedia

β-thalassemias result from diminished β-globin synthesis and are associated with ineffective erythropoiesis and secondary iron overload caused by inappropriately low levels of the iron regulatory hormone hepcidin. The serine protease TMPRSS6 attenuates hepcidin production in response to iron stores....

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Detalles Bibliográficos
Publicado en:Am J Hematol
Main Authors: Schmidt, Paul J, Racie, Tim, Westerman, Mark, Fitzgerald, Kevin, Butler, James S, Fleming, Mark D
Formato: Artigo
Idioma:Inglês
Publicado: BlackWell Publishing Ltd 2015
Assuntos:
Original Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4403964/
https://ncbi.nlm.nih.gov/pubmed/25557851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ajh.23934
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