An RNAi therapeutic targeting Tmprss6 decreases iron overload in Hfe(−/−) mice and ameliorates anemia and iron overload in murine β-thalassemia intermedia

Mutations in HFE lead to hereditary hemochromatosis (HH) because of inappropriately high iron uptake from the diet resulting from decreased hepatic expression of the iron-regulatory hormone hepcidin. β-thalassemia is a congenital anemia caused by partial or complete loss of β-globin synthesis causin...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Schmidt, Paul J., Toudjarska, Iva, Sendamarai, Anoop K., Racie, Tim, Milstein, Stuart, Bettencourt, Brian R., Hettinger, Julia, Bumcrot, David, Fleming, Mark D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2013
Assuntos:
Red Cells, Iron, and Erythropoiesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3655736/
https://ncbi.nlm.nih.gov/pubmed/23223430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-09-453977
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados