An RNAi therapeutic targeting Tmprss6 decreases iron overload in Hfe(−/−) mice and ameliorates anemia and iron overload in murine β-thalassemia intermedia

Mutations in HFE lead to hereditary hemochromatosis (HH) because of inappropriately high iron uptake from the diet resulting from decreased hepatic expression of the iron-regulatory hormone hepcidin. β-thalassemia is a congenital anemia caused by partial or complete loss of β-globin synthesis causin...

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Bibliographic Details
Main Authors: Schmidt, Paul J., Toudjarska, Iva, Sendamarai, Anoop K., Racie, Tim, Milstein, Stuart, Bettencourt, Brian R., Hettinger, Julia, Bumcrot, David, Fleming, Mark D.
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2013
Subjects:
Red Cells, Iron, and Erythropoiesis
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3655736/
https://ncbi.nlm.nih.gov/pubmed/23223430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-09-453977
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