The IRP1-HIF-2α Axis Coordinates Iron and Oxygen Sensing with Erythropoiesis and Iron Absorption

Red blood cell production is a finely tuned process that requires coordinated oxygen- and iron-dependent regulation of cell differentiation and iron metabolism. Here we show that translational regulation of HIF-2α synthesis by IRP1 is critical for controlling erythrocyte number. IRP1 null mice (Irp1...

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Detalhes bibliográficos
Main Authors: Anderson, Sheila A., Nizzi, Christopher P., Chang, Yuan-I, Deck, Kathryn M., Schmidt, Paul J., Galy, Bruno, Damnernsawad, Alisa, Broman, Aimee T., Kendziorski, Christina, Hentze, Matthias W., Fleming, Mark D., Zhang, Jing, Eisenstein, Richard S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3612289/
https://ncbi.nlm.nih.gov/pubmed/23395174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2013.01.007
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