Φορτώνει......
The IRP1-HIF-2α Axis Coordinates Iron and Oxygen Sensing with Erythropoiesis and Iron Absorption
Red blood cell production is a finely tuned process that requires coordinated oxygen- and iron-dependent regulation of cell differentiation and iron metabolism. Here we show that translational regulation of HIF-2α synthesis by IRP1 is critical for controlling erythrocyte number. IRP1 null mice (Irp1...
Αποθηκεύτηκε σε:
Κύριοι συγγραφείς: | , , , , , , , , , , , , |
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Μορφή: | Artigo |
Γλώσσα: | Inglês |
Έκδοση: |
2013
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Θέματα: | |
Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3612289/ https://ncbi.nlm.nih.gov/pubmed/23395174 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2013.01.007 |
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