Iron-Mediated Degradation of IRP2, an Unexpected Pathway Involving a 2-Oxoglutarate-Dependent Oxygenase Activity

Iron regulatory protein 2 (IRP2), a central posttranscriptional regulator of cellular and systemic iron metabolism, undergoes proteasomal degradation in iron-replete cells. The prevailing model postulates that the mechanism involves site-specific oxidation of 3 cysteine residues (C168, C174, and C17...

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Main Authors: Wang, Jian, Chen, Guohua, Muckenthaler, Martina, Galy, Bruno, Hentze, Matthias W., Pantopoulos, Kostas
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2004
Assuntos:
Transcriptional Regulation
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC321427/
https://ncbi.nlm.nih.gov/pubmed/14729944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.3.954-965.2004
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