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Iron-Dependent Degradation of Apo-IRP1 by the Ubiquitin-Proteasome Pathway
Iron regulatory protein 1 (IRP1) controls the translation or stability of several mRNAs by binding to “iron-responsive elements” within their untranslated regions. In iron-replete cells, IRP1 assembles a cubane iron-sulfur cluster (ISC) that inhibits RNA-binding activity and converts the protein to...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1899896/ https://ncbi.nlm.nih.gov/pubmed/17242182 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01111-06 |
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