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Iron-Dependent Degradation of Apo-IRP1 by the Ubiquitin-Proteasome Pathway

Iron regulatory protein 1 (IRP1) controls the translation or stability of several mRNAs by binding to “iron-responsive elements” within their untranslated regions. In iron-replete cells, IRP1 assembles a cubane iron-sulfur cluster (ISC) that inhibits RNA-binding activity and converts the protein to...

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Bibliografski detalji
Glavni autori: Wang, Jian, Fillebeen, Carine, Chen, Guohua, Biederbick, Annette, Lill, Roland, Pantopoulos, Kostas
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2007
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1899896/
https://ncbi.nlm.nih.gov/pubmed/17242182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01111-06
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