Iron-dependent degradation of IRP2 requires its C-terminal region and IRP structural integrity

BACKGROUND: Iron regulatory protein 2 (IRP2), a post-transcriptional regulator of cellular iron metabolism, undergoes iron-dependent degradation via the ubiquitin-proteasome pathway. A stretch of 73 amino acids within the N-terminal domain 1 of the protein was reported to function as an iron sensor....

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Bibliographic Details
Main Authors: Wang, Jian, Chen, Guohua, Lee, Julie, Pantopoulos, Kostas
Format: Artigo
Language:Inglês
Published: BioMed Central 2008
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2267205/
https://ncbi.nlm.nih.gov/pubmed/18226225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2199-9-15
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