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SIRT3 regulates cellular iron metabolism and cancer growth by repressing iron regulatory protein 1

Iron metabolism is essential for many cellular processes including oxygen transport, respiration and DNA synthesis, and many cancer cells exhibit dysregulation in iron metabolism. Maintenance of cellular iron homeostasis is regulated by iron regulatory proteins (IRPs), which control the expression o...

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Detalhes bibliográficos
Publicado no:Oncogene
Main Authors: Jeong, Seung Min, Lee, Jaewon, Schmidt, Paul J., Fleming, Mark D., Haigis, Marcia C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4747239/
https://ncbi.nlm.nih.gov/pubmed/24909164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2014.124
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