SIRT4 has tumor suppressive activity and regulates the cellular metabolic response to DNA damage by inhibiting mitochondrial glutamine metabolism

DNA damage elicits a cellular signaling response that initiates cell cycle arrest and DNA repair. Here we find that DNA damage triggers a critical block in glutamine metabolism, which is required for proper DNA damage responses. This block requires the mitochondrial SIRT4, which is induced by numero...

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Main Authors: Jeong, Seung Min, Xiao, Cuiying, Finley, Lydia W.S, Lahusen, Tyler, Souza, Amanda L., Pierce, Kerry, Li, Ying-Hua, Wang, Xiaoxu, Laurent, Gaëlle, German, Natalie J., Xu, Xiaoling, Li, Cuiling, Wang, Rui-Hong, Lee, Jaewon, Csibi, Alfredo, Cerione, Richard, Blenis, John, Clish, Clary B., Kimmelman, Alec, Deng, Chu-Xia, Haigis, Marcia C.
Formato: Artigo
Idioma:Inglês
Publicado: 2013
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3650305/
https://ncbi.nlm.nih.gov/pubmed/23562301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2013.02.024
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