SIRT3 opposes reprogramming of cancer cell metabolism through HIF1α destabilization

Tumor cells exhibit aberrant metabolism characterized by high glycolysis even in the presence of oxygen. This metabolic reprogramming, known as the Warburg effect, provides tumor cells with the substrates required for biomass generation. Here, we show that the mitochondrial NAD-dependent deacetylase...

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Detalhes bibliográficos
Main Authors: Finley, Lydia W.S., Carracedo, Arkaitz, Lee, Jaewon, Souza, Amanda, Egia, Ainara, Zhang, Jiangwen, Teruya-Feldstein, Julie, Moreira, Paula I., Cardoso, Sandra M., Clish, Clary B., Pandolfi, Pier Paolo, Haigis, Marcia C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3065720/
https://ncbi.nlm.nih.gov/pubmed/21397863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2011.02.014
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