SIRT3 opposes reprogramming of cancer cell metabolism through HIF1α destabilization

Tumor cells exhibit aberrant metabolism characterized by high glycolysis even in the presence of oxygen. This metabolic reprogramming, known as the Warburg effect, provides tumor cells with the substrates required for biomass generation. Here, we show that the mitochondrial NAD-dependent deacetylase...

Volledige beschrijving

Bewaard in:
Bibliografische gegevens
Hoofdauteurs: Finley, Lydia W.S., Carracedo, Arkaitz, Lee, Jaewon, Souza, Amanda, Egia, Ainara, Zhang, Jiangwen, Teruya-Feldstein, Julie, Moreira, Paula I., Cardoso, Sandra M., Clish, Clary B., Pandolfi, Pier Paolo, Haigis, Marcia C.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2011
Onderwerpen:
Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3065720/
https://ncbi.nlm.nih.gov/pubmed/21397863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2011.02.014
Tags: Voeg label toe
Geen labels, Wees de eerste die dit record labelt!

Gelijkaardige items