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Differential p53-independent Outcomes of p19Arf Loss in Oncogenesis
One reported function of the tumor suppressor p19(Arf) is to stabilize p53, providing a critical checkpoint in the response to oncogenic insults. Acute loss of Pten leads to an increase in the abundance of p19(Arf), p53, and p21 proteins as part of a fail-safe senescence response. Here, we report th...
में बचाया:
| मुख्य लेखकों: | , , , , , , , , , , , |
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| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
2009
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2928478/ https://ncbi.nlm.nih.gov/pubmed/19690330 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2000053 |
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