Differential p53-independent Outcomes of p19Arf Loss in Oncogenesis

One reported function of the tumor suppressor p19(Arf) is to stabilize p53, providing a critical checkpoint in the response to oncogenic insults. Acute loss of Pten leads to an increase in the abundance of p19(Arf), p53, and p21 proteins as part of a fail-safe senescence response. Here, we report th...

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Hlavní autoři: Chen, Zhenbang, Carracedo, Arkaitz, Lin, Hui-Kuan, Koutcher, Jason A., Behrendt, Nille, Egia, Ainara, Alimonti, Andrea, Carver, Brett S., Gerald, William, Teruya-Feldstein, Julie, Loda, Massimo, Pandolfi, Pier Paolo
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2928478/
https://ncbi.nlm.nih.gov/pubmed/19690330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2000053
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