SIRT3 opposes reprogramming of cancer cell metabolism through HIF1α destabilization

Tumor cells exhibit aberrant metabolism characterized by high glycolysis even in the presence of oxygen. This metabolic reprogramming, known as the Warburg effect, provides tumor cells with the substrates required for biomass generation. Here, we show that the mitochondrial NAD-dependent deacetylase...

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Main Authors: Finley, Lydia W.S., Carracedo, Arkaitz, Lee, Jaewon, Souza, Amanda, Egia, Ainara, Zhang, Jiangwen, Teruya-Feldstein, Julie, Moreira, Paula I., Cardoso, Sandra M., Clish, Clary B., Pandolfi, Pier Paolo, Haigis, Marcia C.
Format: Artigo
Jezik:Inglês
Izdano: 2011
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3065720/
https://ncbi.nlm.nih.gov/pubmed/21397863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2011.02.014
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