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Pml represses tumour progression through inhibition of mTOR
The promyelocytic leukaemia gene PML is a pleiotropic tumour suppressor. We have recently demonstrated that PML opposes mTOR-HIF1α-VEGF signalling in hypoxia. To determine the relevance of PML-mTOR antagonism in tumourigenesis, we have intercrossed Pml null mice with Tsc2 heterozygous mice, which de...
שמור ב:
| Main Authors: | , , , , , , |
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| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
WILEY-VCH Verlag
2011
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3123467/ https://ncbi.nlm.nih.gov/pubmed/21387562 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.201100130 |
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