Pml represses tumour progression through inhibition of mTOR

The promyelocytic leukaemia gene PML is a pleiotropic tumour suppressor. We have recently demonstrated that PML opposes mTOR-HIF1α-VEGF signalling in hypoxia. To determine the relevance of PML-mTOR antagonism in tumourigenesis, we have intercrossed Pml null mice with Tsc2 heterozygous mice, which de...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Bernardi, Rosa, Papa, Antonella, Egia, Ainara, Coltella, Nadia, Teruya-Feldstein, Julie, Signoretti, Sabina, Pandolfi, Pier Paolo
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: WILEY-VCH Verlag 2011
Pynciau:
Reports
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3123467/
https://ncbi.nlm.nih.gov/pubmed/21387562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.201100130
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