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SIRT3 Controls Cancer Metabolic Reprogramming by Regulating ROS and HIF
In this issue of Cancer Cell, Finley and coworkers report that genetic loss of the deacetylase SIRT3 leads to metabolic re-programming toward glycolysis. This shift is mediated by an increase in cellular reactive oxygen species (ROS) generation that amplifies HIF-α stabilization and HIF-dependent ge...
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3087169/ https://ncbi.nlm.nih.gov/pubmed/21397853 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2011.03.001 |
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