Immunoregulatory protein B7-H3 reprograms glucose metabolism in cancer cells by ROS-mediated stabilization of HIF-1α

B7-H3 is a member of B7 family of immunoregulatory transmembrane glycoproteins expressed by T cells. While B7-H3 overexpression is associated with poor outcomes in multiple cancers, it is also has immune-independent roles outside T cells and its precise mechanistic contributions to cancer are unclea...

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Lim, Sangbin, Liu, Hao, da Silva, Luciana Madeira, Arora, Ritu, Liu, Zixing, Phillips, Joshua B., Schmitt, David C., Vu, Tung, McClellan, Steven, Lin, Yifeng, Lin, Wensheng, Piazza, Gary A., Fodstad, Oystein, Tan, Ming
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4874665/
https://ncbi.nlm.nih.gov/pubmed/27197253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-15-1538
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