The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4

Proliferating mammalian cells use glutamine as a source of nitrogen and as a key anaplerotic source to provide metabolites to the tricarboxylic acid cycle (TCA) for biosynthesis. Recently, mTORC1 activation has been correlated with increased nutrient uptake and metabolism, but no molecular connectio...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Csibi, Alfred, Fendt, Sarah-Maria, Li, Chenggang, Poulogiannis, George, Choo, Andrew Y., Chapski, Douglas J., Jeong, Seung Min, Dempsey, Jamie, Parkhitko, Andrey, Morrison, Tasha, Henske, Elizabeth, Haigis, Marcia, Cantley, Lewis C., Stephanopoulos, Gregory, Yu, Jane, Blenis, John
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3684628/
https://ncbi.nlm.nih.gov/pubmed/23663782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2013.04.023
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados