The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4

Proliferating mammalian cells use glutamine as a source of nitrogen and as a key anaplerotic source to provide metabolites to the tricarboxylic acid cycle (TCA) for biosynthesis. Recently, mTORC1 activation has been correlated with increased nutrient uptake and metabolism, but no molecular connectio...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Csibi, Alfred, Fendt, Sarah-Maria, Li, Chenggang, Poulogiannis, George, Choo, Andrew Y., Chapski, Douglas J., Jeong, Seung Min, Dempsey, Jamie, Parkhitko, Andrey, Morrison, Tasha, Henske, Elizabeth, Haigis, Marcia, Cantley, Lewis C., Stephanopoulos, Gregory, Yu, Jane, Blenis, John
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2013
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3684628/
https://ncbi.nlm.nih.gov/pubmed/23663782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2013.04.023
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