Synthetic lethality of combined glutaminase and Hsp90 inhibition in mTORC1-driven tumor cells

The mammalian target of rapamycin complex 1 (mTORC1) integrates multiple signals from growth factors, nutrients, and cellular energy status to control a wide range of metabolic processes, including mRNA biogenesis; protein, nucleotide, and lipid synthesis; and autophagy. Deregulation of the mTORC1 p...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Proc Natl Acad Sci U S A
Main Authors: Li, Jing, Csibi, Alfredo, Yang, Sun, Hoffman, Gregory R., Li, Chenggang, Zhang, Erik, Yu, Jane J., Blenis, John
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2015
Teme:
PNAS Plus
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4291663/
https://ncbi.nlm.nih.gov/pubmed/25524627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1417015112
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