Synthetic lethality by targeting the RUVBL1/2-TTT complex in mTORC1-hyperactive cancer cells

Despite considerable efforts, mTOR inhibitors have produced limited success in the clinic. To define the vulnerabilities of mTORC1-addicted cancer cells and to find previously unknown therapeutic targets, we investigated the mechanism of piperlongumine, a small molecule identified in a chemical libr...

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Pubblicato in:Sci Adv
Autori principali: Shin, Seung Ho, Lee, Ji Su, Zhang, Jia-Min, Choi, Sungbin, Boskovic, Zarko V., Zhao, Ran, Song, Mengqiu, Wang, Rui, Tian, Jie, Lee, Mee-Hyun, Kim, Jae Hwan, Jeong, Minju, Lee, Jung Hyun, Petukhov, Michael, Lee, Sam W., Kim, Sang Gyun, Zou, Lee, Byun, Sanguine
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Association for the Advancement of Science 2020
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7399646/
https://ncbi.nlm.nih.gov/pubmed/32789167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aay9131
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