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Geldanamycin-Derived HSP90 Inhibitors Are Synthetic Lethal with NRF2
Activating mutations in KEAP1-NRF2 are frequently found in tumors of the lung, esophagus, and liver, where they are associated with aggressive growth, resistance to cancer therapies, and low overall survival. Despite the fact that NRF2 is a validated driver of tumorigenesis and chemotherapeutic resi...
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| Publicado no: | Mol Cell Biol |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7588872/ https://ncbi.nlm.nih.gov/pubmed/32868290 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00377-20 |
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