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Total Synthesis of the Hsp90 Inhibitor Geldanamycin

An enantioselective synthesis of the Hsp90 inhibitor geldanamycin was achieved in 20 linear steps and 2.0% overall yield from 2-methoxyhydroquinone. The synthesis is highlighted by a regio- and stereoselective hydroboration reaction; a Sc(OTf)(3)/Et(3)SiH-mediated pyran ring-opening reaction; an ena...

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Bibliografske podrobnosti
Main Authors: Qin, Hua-Li, Panek, James S.
Format: Artigo
Jezik:Inglês
Izdano: 2008
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2430885/
https://ncbi.nlm.nih.gov/pubmed/18489177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol800749w
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