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Total Synthesis of the Hsp90 Inhibitor Geldanamycin
An enantioselective synthesis of the Hsp90 inhibitor geldanamycin was achieved in 20 linear steps and 2.0% overall yield from 2-methoxyhydroquinone. The synthesis is highlighted by a regio- and stereoselective hydroboration reaction; a Sc(OTf)(3)/Et(3)SiH-mediated pyran ring-opening reaction; an ena...
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| Auteurs principaux: | , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2008
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2430885/ https://ncbi.nlm.nih.gov/pubmed/18489177 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol800749w |
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