mTORC1-Driven Tumor Cells Are Highly Sensitive to Therapeutic Targeting by Antagonists of Oxidative Stress

mTORC1 is a central signaling node in controlling cell growth, proliferation, and metabolism that is aberrantly activated in cancers and certain cancer-associated genetic disorders, such as tuberous sclerosis complex (TSC) and sporadic lymphangioleiomyomatosis. However, while mTORC1-inhibitory compo...

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Vydáno v:Cancer Res
Hlavní autoři: Li, Jing, Shin, Sejeong, Sun, Yang, Yoon, Sang-Oh, Li, Chenggang, Zhang, Erik, Yu, Jane, Zhang, Jianming, Blenis, John
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5518474/
https://ncbi.nlm.nih.gov/pubmed/27197195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-15-2629
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