Focal adhesion- and IGF1R-dependent survival and migratory pathways mediate tumor resistance to mTORC1/2 inhibition

Aberrant signaling by the mammalian target of rapamycin (mTOR) contributes to the devastating features of cancer cells. Thus mTOR is a critical therapeutic target and catalytic inhibitors are being investigated as anti-cancer drugs. Although mTOR inhibitors initially block cell proliferation, cell v...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Mol Cell
Main Authors: Yoon, Sang-Oh, Shin, Sejeong, Karreth, Florian A., Buel, Gwen R., Jedrychowski, Mark P., Plas, David R., Dedhar, Shoukat, Gygi, Steven P., Roux, Philippe P., Dephoure, Noah, Blenis, John
Format: Artigo
Sprog:Inglês
Udgivet: 2017
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5698809/
https://ncbi.nlm.nih.gov/pubmed/28757207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2017.06.033
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker