Focal adhesion- and IGF1R-dependent survival and migratory pathways mediate tumor resistance to mTORC1/2 inhibition

Aberrant signaling by the mammalian target of rapamycin (mTOR) contributes to the devastating features of cancer cells. Thus mTOR is a critical therapeutic target and catalytic inhibitors are being investigated as anti-cancer drugs. Although mTOR inhibitors initially block cell proliferation, cell v...

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Publicado no:Mol Cell
Main Authors: Yoon, Sang-Oh, Shin, Sejeong, Karreth, Florian A., Buel, Gwen R., Jedrychowski, Mark P., Plas, David R., Dedhar, Shoukat, Gygi, Steven P., Roux, Philippe P., Dephoure, Noah, Blenis, John
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5698809/
https://ncbi.nlm.nih.gov/pubmed/28757207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2017.06.033
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