BMP6 treatment compensates for the molecular defect and ameliorates hemochromatosis in Hfe knockout mice

BACKGROUND AND AIMS: Abnormal hepcidin regulation is central to the pathogenesis of HFE hemochromatosis. Hepatic bone morphogenetic protein 6 (BMP6)-SMAD signaling is a main regulatory mechanism controlling hepcidin expression, and this pathway was recently demonstrated to be impaired in Hfe knockou...

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Main Authors: Corradini, Elena, Schmidt, Paul J., Meynard, Delphine, Garuti, Cinzia, Montosi, Giuliana, Chen, Shanzhuo, Vukicevic, Slobodan, Pietrangelo, Antonello, Lin, Herbert Y., Babitt, Jodie L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3295242/
https://ncbi.nlm.nih.gov/pubmed/20682319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2010.07.044
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