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Endothelial Bmp2 knockout exacerbates hemochromatosis in Hfe knockout mice but not Bmp6 knockout mice
Bone morphogenetic proteins BMP2 and BMP6 play key roles in systemic iron homeostasis by regulating production of the iron hormone hepcidin. HFE also regulates hepcidin through a mechanism that intersects with the BMP-SMAD1/5/8 pathway. However, the relative roles of BMP2 compared with BMP6 and whet...
Guardat en:
| Publicat a: | Hepatology |
|---|---|
| Autors principals: | , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2020
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7253321/ https://ncbi.nlm.nih.gov/pubmed/31778583 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.31048 |
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