Synthesis and receptor binding of thiophene bioisosteres of potent GluN2B ligands with a benzo[7]annulene-scaffold

Bằng Baumeister, Sören, Schepmann, Dirk, Wünsch, Bernhard
Xuất bản năm Medchemcomm (2019)

Synthesis of σ Receptor Ligands with a Spirocyclic System Connected with a Tetrahydroisoquinoline Moiety via Different Linkers

Bằng Bergkemper, Melanie, Schepmann, Dirk, Wünsch, Bernhard
Xuất bản năm ChemMedChem (2021)

Synthesis and σ receptor affinity of spiro[[2]benzopyran-1,1′-cyclohexanes] with an exocyclic amino moiety in the 3′-position

Bằng Kronenberg, Elisabeth, Weber, Frauke, Schepmann, Dirk, Wünsch, Bernhard
Xuất bản năm RSC Med Chem (2020)

Do GluN2B subunit containing NMDA receptors tolerate a fluorine atom in the phenylalkyl side chain?

Bằng Shuto, Yoshihiro, Thum, Simone, Temme, Louisa, Schepmann, Dirk, Kitamura, Masato, Wünsch, Bernhard
Xuất bản năm Medchemcomm (2017)

Propellanes as Rigid Scaffolds for the Stereodefined Attachment of σ-Pharmacophoric Structural Elements to Achieve σ Affinity

Bằng Torres-Gómez, Héctor, Daniliuc, Constantin, Schepmann, Dirk, Laurini, Erik, Pricl, Sabrina, Wünsch, Bernhard
Xuất bản năm Int J Mol Sci (2021)

Bioisosteric replacement of central 1,2,4-oxadiazole ring of high affinity CB(2) ligands by regioisomeric 1,3,4-oxadiazole ring

Bằng Heimann, Dominik, Lueg, Corinna, de Vries, Henk, Frehland, Bastian, Schepmann, Dirk, Heitman, Laura H., Wünsch, Bernhard
Xuất bản năm Medchemcomm (2017)

Enantiomerically Pure Quinoline‐Based κ‐Opioid Receptor Agonists: Chemoenzymatic Synthesis and Pharmacological Evaluation

Bằng Martin, Benedikt, Schepmann, Dirk, Bernal, Freddy A., Schmidt, Thomas J., Che, Tao, Loser, Karin, Wünsch, Bernhard
Xuất bản năm ChemMedChem (2020)

Synthesis, Cytotoxicity Evaluation, and Computational Insights of Novel 1,4-Diazepane-Based Sigma Ligands

Bằng Zampieri, Daniele, Fortuna, Sara, Calabretti, Antonella, Romano, Maurizio, Menegazzi, Renzo, Schepmann, Dirk, Wünsch, Bernhard, Mamolo, Maria Grazia
Xuất bản năm ACS Med Chem Lett (2019)

Asymmetric Synthesis of Spirocyclic 2-Benzopyrans for Positron Emission Tomography of σ(1) Receptors in the Brain

Bằng Holl, Katharina, Schepmann, Dirk, Fischer, Steffen, Ludwig, Friedrich-Alexander, Hiller, Achim, Donat, Cornelius K., Deuther-Conrad, Winnie, Brust, Peter, Wünsch, Bernhard
Được phát hành 2014

A common mechanism allows selective targeting of GluN2B subunit-containing N-methyl-D-aspartate receptors

Bằng Schreiber, Julian A., Schepmann, Dirk, Frehland, Bastian, Thum, Simone, Datunashvili, Maia, Budde, Thomas, Hollmann, Michael, Strutz-Seebohm, Nathalie, Wünsch, Bernhard, Seebohm, Guiscard
Xuất bản năm Commun Biol (2019)

Synthesis and Pharmacological Evaluation of Fluorinated Quinoxaline‐Based κ‐Opioid Receptor (KOR) Agonists Designed for PET Studies

Bằng Tangherlini, Giovanni, Börgel, Frederik, Schepmann, Dirk, Slocum, Samuel, Che, Tao, Wagner, Stefan, Schwegmann, Katrin, Hermann, Sven, Mykicki, Nadine, Loser, Karin, Wünsch, Bernhard
Xuất bản năm ChemMedChem (2020)

Design, Radiosynthesis and Preliminary Biological Evaluation in Mice of a Brain-Penetrant (18)F-Labelled σ(2) Receptor Ligand

Bằng Moldovan, Rareş-Petru, Gündel, Daniel, Teodoro, Rodrigo, Ludwig, Friedrich-Alexander, Fischer, Steffen, Toussaint, Magali, Schepmann, Dirk, Wünsch, Bernhard, Brust, Peter, Deuther-Conrad, Winnie
Xuất bản năm Int J Mol Sci (2021)

Setup and Validation of a Reliable Docking Protocol for the Development of Neuroprotective Agents by Targeting the Sigma-1 Receptor (S1R)

Bằng Rossino, Giacomo, Rui, Marta, Pozzetti, Luca, Schepmann, Dirk, Wünsch, Bernhard, Zampieri, Daniele, Pellavio, Giorgia, Laforenza, Umberto, Rinaldi, Silvia, Colombo, Giorgio, Morelli, Laura, Linciano, Pasquale, Rossi, Daniela, Collina, Simona
Xuất bản năm Int J Mol Sci (2020)

Novel Highly Potent and Selective Sigma1 Receptor Antagonists Effectively Block the Binge Eating Episode in Female Rats

Bằng Cifani, Carlo, Micioni Di Bonaventura, Emanuela, Botticelli, Luca, Del Bello, Fabio, Giorgioni, Gianfabio, Pavletić, Pegi, Piergentili, Alessandro, Quaglia, Wilma, Bonifazi, Alessandro, Schepmann, Dirk, Wünsch, Bernhard, Vistoli, Giulio, Micioni Di Bonaventura, Maria Vittoria
Xuất bản năm ACS Chem Neurosci (2020)

In vitro and in vivo Human Metabolism of (S)-[(18)F]Fluspidine – A Radioligand for Imaging σ(1) Receptors With Positron Emission Tomography (PET)

Bằng Ludwig, Friedrich-Alexander, Fischer, Steffen, Houska, Richard, Hoepping, Alexander, Deuther-Conrad, Winnie, Schepmann, Dirk, Patt, Marianne, Meyer, Philipp M., Hesse, Swen, Becker, Georg-Alexander, Zientek, Franziska Ruth, Steinbach, Jörg, Wünsch, Bernhard, Sabri, Osama, Brust, Peter
Xuất bản năm Front Pharmacol (2019)

Role of the NMDA Receptor in the Antitumor Activity of Chiral 1,4-Dioxane Ligands in MCF-7 and SKBR3 Breast Cancer Cells

Bằng Morelli, Maria Beatrice, Amantini, Consuelo, Nabissi, Massimo, Santoni, Giorgio, Wünsch, Bernhard, Schepmann, Dirk, Cimarelli, Cristina, Pellei, Maura, Santini, Carlo, Fontana, Stefano, Mammoli, Valerio, Quaglia, Wilma, Bonifazi, Alessandro, Giannella, Mario, Giorgioni, Gianfabio, Piergentili, Alessandro, Del Bello, Fabio
Xuất bản năm ACS Med Chem Lett (2019)

Development of the First Potential Nonpeptidic Positron Emission Tomography Tracer for the Imaging of CCR2 Receptors

Bằng Wagner, Stefan, de Moura Gatti, Fernando, Silva, Daniel G., Ortiz Zacarias, Natalia V., Zweemer, Annelien J. M., Hermann, Sven, De Maria, Monica, Koch, Michael, Weiss, Christina, Schepmann, Dirk, Heitman, Laura H., Tschammer, Nuska, Kopka, Klaus, Junker, Anna
Xuất bản năm ChemMedChem (2020)