Enantiomerically Pure Quinoline‐Based κ‐Opioid Receptor Agonists: Chemoenzymatic Synthesis and Pharmacological Evaluation

Racemic (K)‐opioid receptor (KOR) agonist 2‐(3,4‐dichlorophenyl)‐1‐[(4aRS,8SR,8aSR)‐8‐(pyrrolidin‐1‐yl)‐3,4,4a,5,6,7,8,8a‐octahydroquinolin‐1(2H)‐yl]ethan‐1‐one ((±)‐4) was prepared in a diastereoselective synthesis. The first key step of the synthesis was the diastereoselective hydrogenation of the...

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Pubblicato in:ChemMedChem
Autori principali: Martin, Benedikt, Schepmann, Dirk, Bernal, Freddy A., Schmidt, Thomas J., Che, Tao, Loser, Karin, Wünsch, Bernhard
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7496650/
https://ncbi.nlm.nih.gov/pubmed/32492288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.202000300
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