Enantiomerically Pure Quinoline‐Based κ‐Opioid Receptor Agonists: Chemoenzymatic Synthesis and Pharmacological Evaluation

Racemic (K)‐opioid receptor (KOR) agonist 2‐(3,4‐dichlorophenyl)‐1‐[(4aRS,8SR,8aSR)‐8‐(pyrrolidin‐1‐yl)‐3,4,4a,5,6,7,8,8a‐octahydroquinolin‐1(2H)‐yl]ethan‐1‐one ((±)‐4) was prepared in a diastereoselective synthesis. The first key step of the synthesis was the diastereoselective hydrogenation of the...

Cijeli opis

Spremljeno u:
Bibliografski detalji
Izdano u:ChemMedChem
Glavni autori: Martin, Benedikt, Schepmann, Dirk, Bernal, Freddy A., Schmidt, Thomas J., Che, Tao, Loser, Karin, Wünsch, Bernhard
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2020
Teme:
Full Papers
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7496650/
https://ncbi.nlm.nih.gov/pubmed/32492288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.202000300
Oznake: Dodaj oznaku
Bez oznaka, Budi prvi tko označuje ovaj zapis!

Similar Items