Synthesis and receptor binding of thiophene bioisosteres of potent GluN2B ligands with a benzo[7]annulene-scaffold

por Baumeister, Sören, Schepmann, Dirk, Wünsch, Bernhard
Publicado en Medchemcomm (2019)

Synthesis of σ Receptor Ligands with a Spirocyclic System Connected with a Tetrahydroisoquinoline Moiety via Different Linkers

por Bergkemper, Melanie, Schepmann, Dirk, Wünsch, Bernhard
Publicado en ChemMedChem (2021)

Synthesis and σ receptor affinity of spiro[[2]benzopyran-1,1′-cyclohexanes] with an exocyclic amino moiety in the 3′-position

por Kronenberg, Elisabeth, Weber, Frauke, Schepmann, Dirk, Wünsch, Bernhard
Publicado en RSC Med Chem (2020)

Do GluN2B subunit containing NMDA receptors tolerate a fluorine atom in the phenylalkyl side chain?

por Shuto, Yoshihiro, Thum, Simone, Temme, Louisa, Schepmann, Dirk, Kitamura, Masato, Wünsch, Bernhard
Publicado en Medchemcomm (2017)

Propellanes as Rigid Scaffolds for the Stereodefined Attachment of σ-Pharmacophoric Structural Elements to Achieve σ Affinity

por Torres-Gómez, Héctor, Daniliuc, Constantin, Schepmann, Dirk, Laurini, Erik, Pricl, Sabrina, Wünsch, Bernhard
Publicado en Int J Mol Sci (2021)

Bioisosteric replacement of central 1,2,4-oxadiazole ring of high affinity CB(2) ligands by regioisomeric 1,3,4-oxadiazole ring

por Heimann, Dominik, Lueg, Corinna, de Vries, Henk, Frehland, Bastian, Schepmann, Dirk, Heitman, Laura H., Wünsch, Bernhard
Publicado en Medchemcomm (2017)

Enantiomerically Pure Quinoline‐Based κ‐Opioid Receptor Agonists: Chemoenzymatic Synthesis and Pharmacological Evaluation

por Martin, Benedikt, Schepmann, Dirk, Bernal, Freddy A., Schmidt, Thomas J., Che, Tao, Loser, Karin, Wünsch, Bernhard
Publicado en ChemMedChem (2020)

Synthesis, Cytotoxicity Evaluation, and Computational Insights of Novel 1,4-Diazepane-Based Sigma Ligands

por Zampieri, Daniele, Fortuna, Sara, Calabretti, Antonella, Romano, Maurizio, Menegazzi, Renzo, Schepmann, Dirk, Wünsch, Bernhard, Mamolo, Maria Grazia
Publicado en ACS Med Chem Lett (2019)

Asymmetric Synthesis of Spirocyclic 2-Benzopyrans for Positron Emission Tomography of σ(1) Receptors in the Brain

por Holl, Katharina, Schepmann, Dirk, Fischer, Steffen, Ludwig, Friedrich-Alexander, Hiller, Achim, Donat, Cornelius K., Deuther-Conrad, Winnie, Brust, Peter, Wünsch, Bernhard
Publicado 2014

A common mechanism allows selective targeting of GluN2B subunit-containing N-methyl-D-aspartate receptors

por Schreiber, Julian A., Schepmann, Dirk, Frehland, Bastian, Thum, Simone, Datunashvili, Maia, Budde, Thomas, Hollmann, Michael, Strutz-Seebohm, Nathalie, Wünsch, Bernhard, Seebohm, Guiscard
Publicado en Commun Biol (2019)

Synthesis and Pharmacological Evaluation of Fluorinated Quinoxaline‐Based κ‐Opioid Receptor (KOR) Agonists Designed for PET Studies

por Tangherlini, Giovanni, Börgel, Frederik, Schepmann, Dirk, Slocum, Samuel, Che, Tao, Wagner, Stefan, Schwegmann, Katrin, Hermann, Sven, Mykicki, Nadine, Loser, Karin, Wünsch, Bernhard
Publicado en ChemMedChem (2020)

Design, Radiosynthesis and Preliminary Biological Evaluation in Mice of a Brain-Penetrant (18)F-Labelled σ(2) Receptor Ligand

por Moldovan, Rareş-Petru, Gündel, Daniel, Teodoro, Rodrigo, Ludwig, Friedrich-Alexander, Fischer, Steffen, Toussaint, Magali, Schepmann, Dirk, Wünsch, Bernhard, Brust, Peter, Deuther-Conrad, Winnie
Publicado en Int J Mol Sci (2021)

Setup and Validation of a Reliable Docking Protocol for the Development of Neuroprotective Agents by Targeting the Sigma-1 Receptor (S1R)

por Rossino, Giacomo, Rui, Marta, Pozzetti, Luca, Schepmann, Dirk, Wünsch, Bernhard, Zampieri, Daniele, Pellavio, Giorgia, Laforenza, Umberto, Rinaldi, Silvia, Colombo, Giorgio, Morelli, Laura, Linciano, Pasquale, Rossi, Daniela, Collina, Simona
Publicado en Int J Mol Sci (2020)

Novel Highly Potent and Selective Sigma1 Receptor Antagonists Effectively Block the Binge Eating Episode in Female Rats

por Cifani, Carlo, Micioni Di Bonaventura, Emanuela, Botticelli, Luca, Del Bello, Fabio, Giorgioni, Gianfabio, Pavletić, Pegi, Piergentili, Alessandro, Quaglia, Wilma, Bonifazi, Alessandro, Schepmann, Dirk, Wünsch, Bernhard, Vistoli, Giulio, Micioni Di Bonaventura, Maria Vittoria
Publicado en ACS Chem Neurosci (2020)

In vitro and in vivo Human Metabolism of (S)-[(18)F]Fluspidine – A Radioligand for Imaging σ(1) Receptors With Positron Emission Tomography (PET)

por Ludwig, Friedrich-Alexander, Fischer, Steffen, Houska, Richard, Hoepping, Alexander, Deuther-Conrad, Winnie, Schepmann, Dirk, Patt, Marianne, Meyer, Philipp M., Hesse, Swen, Becker, Georg-Alexander, Zientek, Franziska Ruth, Steinbach, Jörg, Wünsch, Bernhard, Sabri, Osama, Brust, Peter
Publicado en Front Pharmacol (2019)

Role of the NMDA Receptor in the Antitumor Activity of Chiral 1,4-Dioxane Ligands in MCF-7 and SKBR3 Breast Cancer Cells

por Morelli, Maria Beatrice, Amantini, Consuelo, Nabissi, Massimo, Santoni, Giorgio, Wünsch, Bernhard, Schepmann, Dirk, Cimarelli, Cristina, Pellei, Maura, Santini, Carlo, Fontana, Stefano, Mammoli, Valerio, Quaglia, Wilma, Bonifazi, Alessandro, Giannella, Mario, Giorgioni, Gianfabio, Piergentili, Alessandro, Del Bello, Fabio
Publicado en ACS Med Chem Lett (2019)

Development of the First Potential Nonpeptidic Positron Emission Tomography Tracer for the Imaging of CCR2 Receptors

por Wagner, Stefan, de Moura Gatti, Fernando, Silva, Daniel G., Ortiz Zacarias, Natalia V., Zweemer, Annelien J. M., Hermann, Sven, De Maria, Monica, Koch, Michael, Weiss, Christina, Schepmann, Dirk, Heitman, Laura H., Tschammer, Nuska, Kopka, Klaus, Junker, Anna
Publicado en ChemMedChem (2020)