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Do GluN2B subunit containing NMDA receptors tolerate a fluorine atom in the phenylalkyl side chain?

The influence of an F-atom in the side chain of benzo[7]annulen-7-amines on the affinity towards GluN2B subunit containing NMDA receptors and the selectivity over related receptors was investigated. The synthesis of 5a and 5b was performed by reductive amination of the ketone 6 with primary alkanami...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Medchemcomm
Egile Nagusiak: Shuto, Yoshihiro, Thum, Simone, Temme, Louisa, Schepmann, Dirk, Kitamura, Masato, Wünsch, Bernhard
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Royal Society of Chemistry 2017
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6072303/
https://ncbi.nlm.nih.gov/pubmed/30108812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6md00621c
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