Novel Highly Potent and Selective Sigma1 Receptor Antagonists Effectively Block the Binge Eating Episode in Female Rats

[Image: see text] In this paper, the benzo-cracking approach was applied to the potent sigma1 (σ(1)) receptor antagonist 1 to afford the less conformationally constrained 1,3-dioxane derivatives 2 and 3. To evaluate the effect of the increase in the distance between the two hydrophobic structural el...

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Opis bibliograficzny
Wydane w:ACS Chem Neurosci
Główni autorzy: Cifani, Carlo, Micioni Di Bonaventura, Emanuela, Botticelli, Luca, Del Bello, Fabio, Giorgioni, Gianfabio, Pavletić, Pegi, Piergentili, Alessandro, Quaglia, Wilma, Bonifazi, Alessandro, Schepmann, Dirk, Wünsch, Bernhard, Vistoli, Giulio, Micioni Di Bonaventura, Maria Vittoria
Format: Artigo
Język:Inglês
Wydane: American Chemical Society 2020
Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8011929/
https://ncbi.nlm.nih.gov/pubmed/32886484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.0c00456
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