Novel Potent Muscarinic Receptor Antagonists: Investigation on the Nature of Lipophilic Substituents in the 5- and/or 6-Positions of the 1,4-Dioxane Nucleus

[Image: see text] A series of novel 1,4-dioxane analogues of the muscarinic acetylcholine receptor (mAChR) antagonist 2 was synthesized and studied for their affinity at M(1)–M(5) mAChRs. The 6-cyclohexyl-6-phenyl derivative 3b, with a cis configuration between the CH(2)N(+)(CH(3))(3) chain in the 2...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Del Bello, Fabio, Bonifazi, Alessandro, Giorgioni, Gianfabio, Piergentili, Alessandro, Sabbieti, Maria Giovanna, Agas, Dimitrios, Dell’Aera, Marzia, Matucci, Rosanna, Górecki, Marcin, Pescitelli, Gennaro, Vistoli, Giulio, Quaglia, Wilma
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2020
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8007111/
https://ncbi.nlm.nih.gov/pubmed/32374602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.9b02100
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