Role of the NMDA Receptor in the Antitumor Activity of Chiral 1,4-Dioxane Ligands in MCF-7 and SKBR3 Breast Cancer Cells

[Image: see text] The potent N-methyl-d-aspartate (NMDA) receptor antagonists 1–3 have been demonstrated to show antiproliferative and cytotoxic effects in MCF-7 and SKBR3 breast cancer cell lines. To improve the knowledge about the role played by the NMDA receptor in the antitumor activity of these...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Morelli, Maria Beatrice, Amantini, Consuelo, Nabissi, Massimo, Santoni, Giorgio, Wünsch, Bernhard, Schepmann, Dirk, Cimarelli, Cristina, Pellei, Maura, Santini, Carlo, Fontana, Stefano, Mammoli, Valerio, Quaglia, Wilma, Bonifazi, Alessandro, Giannella, Mario, Giorgioni, Gianfabio, Piergentili, Alessandro, Del Bello, Fabio
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2019
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6466546/
https://ncbi.nlm.nih.gov/pubmed/30996788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.8b00536
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