Repositioning Dequalinium as Potent Muscarinic Allosteric Ligand by Combining Virtual Screening Campaigns and Experimental Binding Assays

Structure-based virtual screening is a truly productive repurposing approach provided that reliable target structures are available. Recent progresses in the structural resolution of the G-Protein Coupled Receptors (GPCRs) render these targets amenable for structure-based repurposing studies. Hence,...

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Bibliographic Details
Published in:Int J Mol Sci
Main Authors: Mazzolari, Angelica, Gervasoni, Silvia, Pedretti, Alessandro, Fumagalli, Laura, Matucci, Rosanna, Vistoli, Giulio
Format: Artigo
Language:Inglês
Published: MDPI 2020
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7503225/
https://ncbi.nlm.nih.gov/pubmed/32825082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21175961
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