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Synthesis of σ Receptor Ligands with a Spirocyclic System Connected with a Tetrahydroisoquinoline Moiety via Different Linkers

With the aim to develop new σ(2) receptor ligands, spirocyclic piperidines or cyclohexanamines with 2‐benzopyran and 2‐benzofuran scaffolds were connected to the 6,7‐dimethoxy‐1,2,3,4‐tetrahydroisoquinoline moiety by variable linkers. In addition to flexible alkyl chains, linkers containing an amide...

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Dettagli Bibliografici
Pubblicato in:ChemMedChem
Autori principali: Bergkemper, Melanie, Schepmann, Dirk, Wünsch, Bernhard
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2021
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8048568/
https://ncbi.nlm.nih.gov/pubmed/33332704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.202000861
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