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Synthesis of σ Receptor Ligands with a Spirocyclic System Connected with a Tetrahydroisoquinoline Moiety via Different Linkers

With the aim to develop new σ(2) receptor ligands, spirocyclic piperidines or cyclohexanamines with 2‐benzopyran and 2‐benzofuran scaffolds were connected to the 6,7‐dimethoxy‐1,2,3,4‐tetrahydroisoquinoline moiety by variable linkers. In addition to flexible alkyl chains, linkers containing an amide...

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Vydáno v:ChemMedChem
Hlavní autoři: Bergkemper, Melanie, Schepmann, Dirk, Wünsch, Bernhard
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2021
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8048568/
https://ncbi.nlm.nih.gov/pubmed/33332704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.202000861
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