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Asymmetric Synthesis of Spirocyclic 2-Benzopyrans for Positron Emission Tomography of σ(1) Receptors in the Brain

Sharpless asymmetric dihydroxylation of styrene derivative 6 afforded chiral triols (R)-7 and (S)-7, which were cyclized with tosyl chloride in the presence of Bu(2)SnO to provide 2-benzopyrans (R)-4 and (S)-4 with high regioselectivity. The additional hydroxy moiety in the 4-position was exploited...

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Detalhes bibliográficos
Main Authors: Holl, Katharina, Schepmann, Dirk, Fischer, Steffen, Ludwig, Friedrich-Alexander, Hiller, Achim, Donat, Cornelius K., Deuther-Conrad, Winnie, Brust, Peter, Wünsch, Bernhard
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3915196/
https://ncbi.nlm.nih.gov/pubmed/24451404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ph7010078
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